Recombinant Human 2-5A-dependent ribonuclease (RNASEL), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 63.4kDa. Partial: 330-741aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.