Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein (TNFRSF1A) (Active)
Description
Purity > 97% as determined by SDS-PAGE and HPLC. MW: 21.2kDa. Partial: 22-211aa. tag-Free. Homo sapiens (Human). Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55