Recombinant Human Tumor necrosis factor receptor superfamily member 10B protein (TNFRSF10B) (Active)
Description
Purity > 97% as determined by SDS-PAGE and HPLC. MW: 14.8kDa. Partial: 52-183aa. tag-Free. Homo sapiens (Human). Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Death receptor 5, TRAIL receptor 2, TRAIL-R2, CD antigen CD262,