A ferroptosis inducer; induces ferroptotic cell death in vitro, an effect that can be blocked by ferroptosis inhibitors; inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells at 5 μM; inhibits glutamate release via the cystine-glutamate transporter in an enzyme-coupled fluorescence assay (EC50 = 1.2 μM); selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 μg/ml)
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
oncoprotein oncogene Ras antitumor cancer mitochondrial oxidative injury anti tumor