S5-1 was raised against a synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31)-The antibody has been shown to inhibit the binding of C5a to its receptor-Aliases Complement component 5a receptor 1-CD88-C5aR-C5a anaphylatoxin receptor
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Description
The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor of 45kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding G-protein-dependent cellular responses are initiated 2+ such as increased intracellular Ca , granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis.