Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1000
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Description
Pan SUMO Polyclonal Antibody. Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT
Immunogen
n/a
Other Names
Small ubiquitin-related modifier 1; SUMO-1; Ubiquitin-like protein SMT3C; SMT3 homolog 3; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein UBL1; GAP modifying protein 1; GMP1; Sentrin; SMT3C; SMT3H3; UBL1; Small ubiquitin-related modifier 2; SUMO-2; Ubiquitin-like protein SMT3B; SMT3 homolog 2; Sentrin-2; HSMT3; SUMO-3; SMT3B; SMT3H2; Small ubiquitin-related modifier 3; SUMO-3; Ubiquitin-like protein SMT3A; SMT3 homolog 1; SUMO-2; SMT3A; SMT3H1