Recombinant Mycobacterium paratuberculosis DNA integrity scanning protein DisA (disA)
Description
Purity > 85% as determined by SDS-PAGE. MW: 45.9kDa. Full Length: 1-357aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10). Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.