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Description
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane, Multi-pass membrane protein.Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. DISEASE: Defects in TMC6 are a cause of epidermodysplasia verruciformis. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Also known as: TMC6, EVER1, Epidermodysplasia verruciformis protein 1, Protein LAK-4, EVIN1.
Immunogen
A synthetic peptide from the 2d cytoplasmic loop of human transmembrane channel-like protein 6 (TMC6, EVER1, Protein LAK-4, EVIN1) conjugated to an immunogenic carrier protein was used as the antigen.