Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:500-1:3000
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Description
TGR5 Polyclonal Antibody. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
Immunogen
n/a
Other Names
BG37, GPCR19, GPR131, M-BAR, TGR5, G-protein coupled bile acid receptor 1, G-protein coupled bile acid receptor BG37, G-protein coupled receptor GPCR19, hBG37, hGPCR19, membrane bile acid receptor, membrane-type receptor for bile acids