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Description
TRIM28 Polyclonal Antibody. TRIM28, also known as KAP-1, is a member of the Transcriptional Intermediary Factor 1 (TIF1) subfamily and contains a RING finger, B box, Coiled coil, PHD/TTC, and bromodomain. TRIM28 is a corepressor for Kruppel-associated box (KRAB)-domain-containing zinc finger proteins and plays a critical role in early embryogenesis. TRIM28 acts as a transcriptional mediator by binding liganded nuclear receptors, including retinoic acid (RAR), retinoid X (RXR) and estrogen (ER) receptors. TRIM28 associates with both heterochromatin and euchromatin, causing gene silencing by both HP1 binding and histone deacetylation.
Immunogen
n/a
Other Names
TRIM28, Tripartite motif containing 28, KRAB-associated protein 1, KAP-1, KRAB-interacting protein 1, KRIP-1, RING finger protein 96, TIF1-beta