Recombinant Human Steroid hormone receptor ERR1 (ESRRA)
Description
Purity > 90% as determined by SDS-PAGE. MW: 72.5kDa. Full Length: 1-423aa. N-terminal GST-tagged. Homo sapiens (Human). Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.