If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
TNFRSF1B(Tumor Necrosis Factor Receptor Subfamily Member 1B), also known as TNFR2 or TNFBR, is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. By linkage analysis, Santee and Owen Schaub(1996) confirmed the mapping of the TNFR2 gene to 1p36.3-p36.2. TNFBR(TNFR75) is the larger of the 2 TNF receptors. It is present on many cell types, especially those of myeloid origin, and is strongly expressed on stimulated T and B lymphocytes. Beltinger et al.(1996) noted that TNFR2 is the main TNF receptor found on circulating T cells and is the major mediator of autoregulatory apoptosis in CD8+ cells. TNFR2 may act with TNFR1 to kill nonlymphoid cells.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse TNF Receptor II(38-55aa YECQISQEYYDRKAQMCC), different from the related rat sequence by three amino acids.