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| Antigenic Specificity | Checkpoint Kinase 1 (CHEK1) (Middle Region) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | antigen affinity purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | ELISA,Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The CHEK1 (Serine/threonine-protein kinase Chk1) is involved in cell cycle arrest when DNA damage has occurred or when unligated DNA is present. It binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2cyclin B complex and prevents mitotic entry. The CHEK1 phosphorylates CDC25C on serine-216. |
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| Immunogen | Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to Middle residues of human CHEK1 (Serine/threonine-protein kinase Chk1) |
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| Other Names | An08g10320|AO090003000441|CHK1|chk1|C85740|Chk1|rad27|id:ibd2720|zgc:56093|CHEK1 |
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| Gene, Accession # | Gene ID: 1111 |
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| Catalog # | ABIN965881 |
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| Price | |
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| Order / More Info | Checkpoint Kinase 1 (CHEK1) (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 9278511, 9382850 |
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