Recombinant Human Breast cancer metastasis-suppressor 1 (BRMS1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 54.3kDa. Partial: 1-235aa. N-terminal GST-tagged. Homo sapiens (Human). Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.