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Description
CDH1 is a classical member of the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised consists of 5 cadherin repeats in the extracellular domain, one trans membrane domain, and a and a highly conserved intracellular domain that binds b-catenin and p120-catenin. CDH1 is involved in mechanisms regulating proliferation, mobility and cell-cell adhesions of epithelial cells. Loss of E-cadherin function or expression has been implicated in cancer metastasis and progression.Synonyms: ARC-1, CAM 120/80, CD324, CDH1, cdhc-A, CDHE, ECAD, E-Cad E-cadherin, Epithelial cadherin, l-cam, LCAM, P09803, P12830 / Q9R0T4, UVO, Uvomorulin, XBcad, XB-cadherin, XTCAD-1 antibody.Ensembl identifier: ENSG00000039068
Immunogen
Purified recombinant peptide derived from within residues 750 to 850 of human CDH1 produced in E. coli.