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Description
SPINK5 Polyclonal Antibody. Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.
Immunogen
n/a
Other Names
Hemofiltrate peptide HF7665, ISK5, LEKTI, Lympho-epithelial Kazal-type-related inhibitor, Lymphoepithelial Kazal type related inhibitor, NETS, NS, Serine peptidase inhibitor Kazal type 5, SPINK5, VAKTI