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Description
Rabbit IgG polyclonal antibody for Arginase-1(ARG1) detection. Tested with WB in Mouse;Rat. No cross reactivity with other proteins. ARG1(arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. The isoform encoded by ARG1, referred to as the liver, or A-I, isoform, contributes 98% of the arginase activity in liver but is also present in red cells. Using a rat liver ARG1 cDNA clone to probe a human liver cDNA library, Haraguchi et al.(1987) isolated and characterized a cDNA corresponding to the ARG1 gene. The ARG1 gene is mapped on 6q23.2 and the arginase gene contains 8 exons. By immunologic studies, 90% of the arginase in red blood cell and liver was precipitated by the antibody, whereas only 50% of the arginase in kidney, brain, and the gastrointestinal tract reacted with it. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of rat liver Arginase(307-323aa KREGNHKPETDYLKPPK), different from the related mouse sequence by two amino acids.
Other Names
Arginase-1;3.5.3.1;Liver-type arginase;Type I arginase;Arg1;