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Description
Bcl1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclindependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of Bchronic lymphocytic leukemia (BCLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma. Description: Supernatant. Synonyms: Polyclonal Cyclin D1 antibody, Anti-Cyclin D1 antibody, G1/S-specific cyclin-D1 antibody, PRAD1 oncogene antibody, BCL-1 oncogene antibdoy.
Immunogen
Cyclin D1 antibody was raised in mouse using recombinant Human PRAD1/cyclin D1 expressed in E. coli as the immunogenSupernatant