CAR, Fc Chimera, Recombinant, Mouse (Coxsackie Adenovirus Receptor)
Description
Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤ 1EU/1ug. CAR (coxsackie and adenovirus receptor), also known as CXADR, is a 46 kD type I transmembrane glycoprotein that belongs to the CTX family of the Ig superfamily (1-3). CAR has received attention as a receptor that facilitates gene transfer mediated by most adenoviruses (1, 2). It is also an adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs (1, 2, 4). CAR is essential for normal cardiac development in the mouse (7). It is expressed throughout brain neuroepithelium during development, but mainly in ependymal cells in the adult (4-6). The 365 amino acid (aa) mouse CAR contains a 19 aa signal sequence, a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain. D1 is thought to be responsible for homodimer formatio