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Description
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis . In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function . While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors . Amplification of the p63 gene is frequently observed in squamous cell carcinomas of the lung, head and neck . The p63 gene contains an alternative transcription intiation site that yields a 40 kDa deltaNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the alpha, beta and gamma isoforms . Synonyms: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L,