Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunocytochemistry (ICC)
Reviews / Ratings
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Description
TP63(Tumor Protein p63), also known as KET, is a protein that in humans is encoded by the TP63 gene. Yang et al.(1998) described the cloning of tumor protein p63, which shows strong homology to the tumor suppressor p53 and the p53-related protein p73. By fluorescence in situ hybridization, Yang et al.(1998) localized the human TP63 gene to chromosome 3q27-q29. Hibi et al.(2000) stated that p53 homologs known variously as p40, p51, p63, and p73L(Trink et al., 1998, Yang et al., 1998, Osada et al., 1998, Senoo et al., 1998) are isoforms of the same gene, which Hibi et al.(2000) referred to as AIS for amplified in squamous cell carcinoma.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human p63(664-680aa DMDARRNKQQRIKEEGE), different from the related rat and mouse sequences by one amino acid.