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Description
The entry of eukaryotic cells into mitosis is regulated by cdc2 kinase activation, a process controlled at several steps including cyclin binding and phosphorylation of cdc2 at Thr161 . However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of cdc2 at Thr14 and Tyr15 . Phosphorylation at Thr14 and Tyr15, resulting in inhibition of cdc2, can be carried out by Wee1 and Myt1 protein kinases . The cdc25 phosphatase may be responsible for removal of phosphates at Thr14 and Tyr15 and subsequent activation of cdc2 . Synonyms: CDC2,CDC28A,CDK1,DKFZp686L20222,MGC111195 ,
Immunogen
Center-peptide of human CDK1
Other Names
5363|CDC2|CDCDm|CDK1|CDK1/CDC2|CG5363|Cdc2|Cdk-1|Cdk1|Dcdc2|Dm cdc2|DmCdc2|DmCdk1|Dmcdc2|Dmel\\CG5363|cdc|cdc2Dm|cdk1|dCdk1|group 4|l(2)31Eh|CDC28A|P34CDC2|Cdc2a|p34|cdc2|wu:fc30e01|zgc:92032|PSTAIR|cdc-2|cdc2-a|cdc28a|cdc2x1.1|p34cdc2|xcdc2|CDC2A|CDC2AAT|CDK2|CDKA1|CDKA;1|CYCLIN-DEPENDENT KINASE A;1|cell division control 2|POL3|pold