An orally bioavailable tyrosine kinase inhibitor that inhibits Abl1 (IC50 = 0.8 nM), Abl1T315I (IC50 = 4 nM), and Abl1H396P; also inhibits the Src family kinases Src, Lyn, Fgr, and Hck and the tyrosine kinases KDR, FLT3, and Tie2 at nanomolar concentrations