Immunofluorescence: 20 μg/mL, Immunohistochemistry: 5 μg/mL, Western Blot: 1 μg/mL
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Description
TCF3 Polyclonal Antibody. The TCF3 gene, also called E2A, encodes two basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. These transcription factors are involved in mediating canonical Wnt signaling, which is very important in a diverse array of cellular functions such as stem cell proliferation, self-renewal, activation, fate determination, differentiation and aging and senescence. They bind beta-catenin and can act as transcriptional activators or repressors for Wnt target genes, and have been shown to regulate specific target genes during CNS development downstream of Wnt signaling. TCF3/Lef complexes are also known to play key roles in controlling cell fate lineages in multipotent skin stem c
Immunogen
n/a
Other Names
E2A, E47, ITF1, TCF-3, VDIR, bHLHb21; VDR interacting repressor; class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; immunoglobulin transcription factor 1; kappa-E2-binding factor; negative vitamin D response element-binding protein; transcription factor E2-alpha; transcription factor ITF-1; vitamin D receptor-interacting repressor