Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunoprecipitation: 1:100-1:500, Western Blot: 1:1000-1:3000
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Description
TCF3 Polyclonal Antibody. TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.