An orally bioavailable inhibitor of STAT3 (32 and 62% inhibition at 10 and 20 μM, respectively, in MDA-MB-231 cells in a luciferase reporter assay); inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer and AsPC-1 and PANC-1 pancreatic cancer cells (IC50s = 0.91, 1.64, 1.9, and 1.08 μM, respectively); inhibits tumor growth in a breast cancer mouse xenograft model at doses of 7.5 mg/kg, i.p. or 25 mg/kg, p.o.; inhibits tumor growth in an orthotopic mouse model of squamous cell carcinoma
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
1420290-88-5 HJC-0152 STAT-3 MDAMB231 MCF7 AsPC1 PANC1 SCC signal transducer and activator of transcription