DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) drug conjugate
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Description
Anti-CD44 (clone BIWA 4)-DM1 ADC. This Antibody-Drug Conjugate (ADC) product is comprised of an anti-CD44 monoclonal antibody (clone BIWA 4) conjugated via a linker to DM1. The DM1 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM1 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.