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Description
Goat Anti-Human APP (C-terminal) polyclonal antibody for ELISA, IHC, WB. The amyloid precursor protein (APP) is a large membrane protein whose C-terminus projects into the extracellular space. In Alzheimer`s disease (AD), the APP is proteolytically cleaved at the N-terminal of Aβ by β-secretase (BACE) to release a ~100 kD APPsβ protein into the extracellular space. The remaining 12 kD fragment remains membrane bound where it can be cleaved at its C-terminus by β-secretase (presenilins) to release the insoluble Aβ peptide into the extracellular space with the ~8 kD APP C-terminal fragment (CTFβ) remaining membrane bound. The APP is the subject of intensive investigations to determine how this protein is broken down abnormally in AD brains to give rise to Aβ, which is present in senile plaques and vessels.