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Description
The recently isolated neurofibromatosis 2 tumor suppressor gene encodes a 595 amino acid protein (Merlin). The protein product Merlin, named for its relatedness to the ezrin, radixin and moesin (ERM) family of proteins, is a tumor suppressor whose absence results in the occurrence of multiple tumors of the nervous system, particularly schwannomas and meningiomas. Merlin's similarity to ERM's suggests that it might share functions, acting as a link between cytoskeletal components and the cell membrane. The NF2 protein is highly expressed in human fibroblasts and is detected as a single band of about 75kDa. This antibody is specific for the phosphorylated form of human NF2 (Merlin).Synonyms: ACN antibody, BANF antibody, SCH, bilateral acoustic neuroma antibody, moesin ezrin radixin like protein antibody, Moesin ezrin radizin like protein antibody, Neurofibromatosis 2 antibody
Immunogen
Human NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to Keyhole Limpet Hemocyanin (KLH).