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Description
NLRC4 Polyclonal Antibody. In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
Immunogen
n/a
Other Names
CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF, CARD, LRR, and NACHT-containing protein, ICE-protease activating factor, NLR family CARD domain-containing protein 4, NOD-like receptor C4, caspase recruitment domain family, member 12, caspase recruitment domain-containing protein 12, ice protease-activating f