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Description
Epitope: extracellular domain, EGF repeats #5-7 [see depositor notes]. This antibody was generated against the extracellular domain of Notch containing the EGF repeats # 5-7. The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain (NICD) is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.
Immunogen
Recombinant fusion protein containing the EGF repeats #5-7: Partial protein