Immunohistochemistry: 2-4 μg/mL, peptide-ELISA: 1:4000, Western Blot: 0.1-0.3 μg/mL
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Description
AKR1C4 Polyclonal Antibody. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Immunogen
n/a
Other Names
AKR1C4; aldo-keto reductase family 1, member C4; HGNC:387; 3-alpha-HSD; C11; CDR; CHDR; DD4; HAKRA; MGC22581; 3-alpha hydroxysteroid dehydrogenase, type I ; 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4; 3-alpha-hydroxysteroid dehydrogenase variant; aldo-keto reductase family 1, member C4; chlordecone reductase; dihydrodiol dehydrogenase 4; dihydrodiol dehydrogenase isozyme DD4; type I 3-alpha-hydroxysteroid dehydrogenase;