Immunocytochemistry: Assay-Dependent, Immunofluorescence: Assay-Dependent, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500
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Description
DIABLO Monoclonal Antibody (78-1-118). Smac/DIABLO, a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms (2,3).
Immunogen
n/a
Other Names
Smac, Second mitochondria-derived activator of caspase, Smac protein, Direct IAP-binding protein with low pI