Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000
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Description
Periostin Monoclonal Antibody (OTI2B2). Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth
Immunogen
n/a
Other Names
Fasciclin-I like;MGC119510;MGC119511;OSF 2;OSF-2;OSF2;Osteoblast specific factor 2 (fasciclin I like);osteoblast specific factor 2 (fasciclin I-like);Osteoblast specific factor 2;Osteoblast specific factor;Osteoblast-specific factor 2;PDLPOSTN;Periodontal ligament specific periostin;Periostin;Periostin isoform thy2;Periostin isoform thy4;Periostin isoform thy6;Periostin isoform thy8;Periostin osteoblast specific factor;PN;POSTN;POSTN_HUMAN;RP11 412K4.1;