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Description
CD263 (TRAIL-R3) Monoclonal Antibody (TRAIL-R3-02). TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
Immunogen
n/a
Other Names
CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID