Immunohistochemistry (Paraffin): 2.5-5.0 μg/mL, Western Blot: 2.5-5.0 μg/mL
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Description
BAK Polyclonal Antibody. Bak or Bcl-2-homologous antagonist is a member of the Bcl-2 family of holologous proteins which function in the regulation of apoptosis. The Bcl-2 related proteins interact with one another through the formation of homo- and heterodimers. The susceptibility of cells to apoptotic stimuli is thought to be controlled by the relative ratios of the different Bcl-2 family proteins. Bak is a 211 aa protein which has been demonstrated to accelerate the rate of apoptosis in growth factor deprived murine lymphoid, neuronal and fibroblastic cell lines. Bak has been localized by immunohistochemistry to the cytosol of cells and stains in a punctate pattern characteristic of other bcl-2 family proteins, which have been localized
Immunogen
n/a
Other Names
BCL2-like 7 protein, apoptosis regulator BAK, bcl-2 homologous antagonist/killer, bcl-2-like protein 7, bcl2-L-7, pro-apoptotic protein BAK