Recombinant Human Cyclic AMP-dependent transcription factor ATF-2
Description
1-505aa; Full Length. MW: 70.5kD. Purity >90% as determined by SDS-PAGE. Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addit
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.Maekawa T., Sakura H., Kanei-Ishii C., Sudo T., Yoshimura T., Fujisawa J., Yoshida M., Ishii S.EMBO J. 8:2023-2028(1989) Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus.Yang L., Lanier E.R., Kraig E.J. Immunol. 158:2522-2525(1997) Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor