Recombinant Human Cyclic GMP-AMP synthase (CGAS), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 58.3kDa. Partial: 161-522aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G (2',5')pA (3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Short name:cGAMP synthase; Short name:cGAS; Short name:h-cGAS; Alternative name (s); 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1