Recombinant Human Cyclic nucleotide-gated cation channel alpha-4 (CNGA4)
Description
Purity > 90% as determined by SDS-PAGE. MW: 82kDa. Full Length: 1-575aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).