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Description
PTMA Polyclonal Antibody. Prothymosinα(PTα) is a nuclear protein that iswidely expressed inmammalian tissues, including kidney, liver,spleen, normal lymphocytes, human T cellleukemia virus-infected T cells andmyeloma cells. The human PTα genemapsto chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlatesto transcription sites. PTα is a chromatin-remodeling protein that wasinitiallythought to mediate T lymphocyte maturation,butsubsequently has been shown to be involved in cellcycle progression,proliferation and cell differentiation. PTα isthought to be transported into the nucleus bythe karyopherin β1-Rch-1 complex,where it associates with Histones H2A, H2B, H3 and H
Immunogen
n/a
Other Names
Prothymosin alpha; Cleaved into the following 2 chains; Prothymosin alpha, N-terminally processed; Thymosin alpha-1; PTMA; TMSA