bovine, feline, human, mouse, nonhuman primate, rat
Isotype
n/a
Format
purified
Size
100 ug
Concentration
n/a
Applications
Immunohistochemistry (Paraffin): 5 μg/mL, Western Blot: 1-3 μg/mL
Reviews / Ratings
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Description
HOXB4 Polyclonal Antibody. HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
Immunogen
n/a
Other Names
HOX-2.6, HOX2, HOX2F, homeo box 2F, homeo box B4, homeobox protein Hox-2.6, homeobox protein Hox-2F, homeobox protein Hox-B4