Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1000
Reviews / Ratings
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Description
Phospho-HNF4A (Ser313) Polyclonal Antibody. Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4 alpha, in association with PGC-1 alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4 alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4 alpha have been linked to maturity-onset diabetes of the young (MODY).
Immunogen
n/a
Other Names
Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14