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Description
TWIST1 Polyclonal Antibody. TWIST1 acts as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
Immunogen
n/a
Other Names
ACS3, BPES2, BPES3, CRS1, SCS, TWIST, bHLHa38, TWIST1, H-twist, class A basic helix-loop-helix protein 38, twist-related protein 1, B-HLH DNA binding protein, TWIST homolog of drosophila, twist homolog 1 (Drosophila)