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Description
Phospho-c-Raf (Ser301) Polyclonal Antibody. The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK (Marshall, 1996). Previous studies have shown that phosphorylation is required for Raf-1 activation (Dhillon and Kolch, 2002; Chon et al, 2003). Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf (Dougherty et al, 2005) with two sites participating Ser 301 and Ser 642.
Immunogen
n/a
Other Names
Craf 1 transforming gene, Craf1 transforming gene, Murine sarcoma 3611 oncogene 1, Raf proto oncogene serine/threonine protein kinase, vraf1 murine le