Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1000
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Description
Phospho-IkB alpha (Tyr42) Polyclonal Antibody. IkB-alpha is a 40 kDa protein that functions to inhibit NF- kappaB activity. The inhibition occurs via protein-protein interaction between I kappaB proteins and NF- kappaB dimers in the cytosol. The interaction of I kappa B-alpha with NF- kappaB masks the nuclear localization sequence of NF- kappaB, preventing NF- kappaB translocation to the nucleus. A variety of stimuli can activate gene expression by liberating NF- kappaB through the degradation of I kappaB alpha. These stimuli include the proinflammatory cytokines TNF- alpha and IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, as well as various chemical and physical stresses. In humans, the gene is located o
Immunogen
n/a
Other Names
I kappa B alpha, I kappa B alpha, I(Kappa)B(alpha), I(Kappa)B(alpha), I-kappa-B-alpha, IkappaBalpha, IkB-alpha, IKBA, IKBA, IKBA, IKBalpha, MAD 3, MAD 3, MAD3, Major histocompatibility complex enhancer binding protein MAD3, Major histocompatibility complex enhancer binding protein MAD3, Major histocompatibility complex enhancer-binding protein MAD3, NF kappa B inhibitor alpha, NF-kappa-B inhibitor alpha, NFKBI, NFKBI, NFKBIA, NFKBIA, Nuclear factor of kappa light chain gene enhancer in B c