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Description
Phospho-IKK alpha (Ser176, Ser180) Polyclonal Antibody. Nuclear factor kappa B (NF-kappa-B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-a and bacteria product LPS. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. The long-sought Ikappa-B kinase (IKK), which phosphorylates Ikappa-B, and mediates Ikappa-B degradation and NF-kappa-B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (
Immunogen
n/a
Other Names
FLJ40509, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKBKB, IKK-B, IKK-beta, IKK2, IKKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, MGC131801, NFKBIKB, Nuclear facto