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Description
PXR Polyclonal Antibody. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characteri
Immunogen
n/a
Other Names
BXR;Nr1i2;NR1I2_HUMAN;Nuclear receptor subfamily 1 group I member 2;ONR 1;ONR1;Orphan nuclear receptor PAR 1;Orphan nuclear receptor PAR1;Orphan nuclear receptor PXR;PAR 1;PAR 2;PAR;PAR q;PAR1;PAR2;PARq;pregnane X nuclear receptor variant 2;Pregnane X receptor;PRR;PXR;SAR;Steroid and xenobiotic receptor;SXR;