Purified (~70-90%). NDR or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFa receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. NDR is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity. Source: Recombinant protein corresponding to human NDR, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~81kD Specific Activity: 4nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)