Recombinant Human E3 ubiquitin-protein ligase CBL (CBL) , partial
Description
MW: 99,633 Da. Purity >85% (SDS-PAGE). The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Size
n/a
Concentration
n/a
Applications
n/a
Other Names
[E3 ubiquitin-protein ligase CBL; E3 ubiquitin-protein ligase CBL; E3 ubiquitin-protein ligase CBL; Cbl proto-oncogene; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBLCurated; Signal transduction protein CBL]