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Description
Axin1 Polyclonal Antibody, Alexa Fluor? 488 Conjugated. ? Target Background: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tu
Immunogen
KLH conjugated synthetic peptide derived from human Axin1 . Immunogen Range: 830-862/862
Other Names
AXIN; PPP1R49; Axin-1; Axis inhibition protein 1; hAxin; AXIN1